Francis Collins
Director, National Institutes of Health
Speaker
Francis Sellers
Collins, MD, PhD is the Director of the National
Institutes of Health (NIH) and former director of the National Human Genome
Research Institute (NHGRI). He is an American physician-geneticist, noted for his
landmark discoveries of disease genes and his leadership of the Human Genome
Project (HGP).
Francis
Collins earned a BS in Chemistry from the University of
Virginia in 1970 and PhD
in physical
chemistry at Yale
University in 1974. While at Yale, he changed
fields and enrolled in medical school at the University of
North Carolina, earning an MD in 1977. From 1978 to
1981, Collins served a residency and chief residency in internal medicine at North
Carolina Memorial Hospital. He then returned to Yale, as Fellow in
Human Genetics at the medical school from 1981 to 1984. During that time, Collins
developed innovative methods of crossing large stretches of DNA to identify
disease genes that have developed into key components of modern molecular
genetics.
Together
with Lap-Chee Tsui and Jack Riordan of the Hospital for
Sick Children in Toronto, Canada, Dr Collins has played a key role
in the identification of the gene for cystic fibrosis and the
isolation of the genes for Huntington's
disease, neurofibromatosis,
multiple
endocrine neoplasia type 1, and the M4 type of adult acute leukemia.
Dr
Collins led the successful effort to complete Human Genome Project (HGP), mapping and
sequencing all of the human DNA, and determining aspects of its function. All the
data collected by the project is now available to the scientific community
without restrictions on access or use. Dr Collins is now leading NHGRI’s effort
to ensure that this new data is translated into tools and strategies to advance
biological knowledge and improve human health.
Collins
has written a book about his Christian faith. He founded and was president of
the BioLogos
Foundation before accepting the nomination to lead the NIH. On
October 14, 2009, Pope Benedict
XVI appointed Francis Collins to the Pontifical
Academy of Sciences. He is a member of the Institute of Medicine and
the National Academy of Sciences, and been awarded the Presidential Medal of
Freedom and the National Medal of Science, the highest honour for scientists by
US government.
Presentation Summary
Technological
advance are altering the prevention and management of chronic disease.
The
ability to cheaply and rapidly sequence DNA means that hundreds of risk factors
for chronic conditions have been identified, allowing individualised disease
risk assessments and pre-emptive behaviour changes.
Progress
towards the development of a universal human flu vaccine is being made, with
vaccines that target the enduring stem of the virus, rather than its
ever-changing external variations
Examination
of the potential for successful antiviruls to manage the infection rate of HIV
Aids are showing significant success rates.
Using
technology to ensure patient compliance in following health management regimes
demonstrates improved healthcare outcomes.
The
development of a vaccine against nicotine addiction will have an impact in
regions of the world where nicotine addiction is implicated in up to 25% of
male deaths.
How
should crucial chronic disease research projects like these be prioritised for
maximum health and social gain among the largest possible populations?