Emerging Technologies

Combination therapy: what is it and why is it important?

A health worker checks a blood sample for malaria in the only hospital in Pailin in western Cambodia January 28, 2010. Bordering with Thailand, this former Khmer Rouge stronghold and dusty gem mining town is now better known for a malarial parasite that is worrying health experts in the region. Studies and research show artemisinin-based therapies - currently the most effective treatment against malaria - are taking longer to cure some of the patients. REUTERS/Damir Sagolj (CAMBODIA - Tags: HEALTH POLITICS SOCIETY) - RTR29KVT

A health worker checks a blood sample Image: REUTERS/Damir Sagolj

Ziba Kashef
Senior Writer, Editor and Communications Consultant, Yale University Office of Public Affairs and Communications
Share:
Our Impact
What's the World Economic Forum doing to accelerate action on Emerging Technologies?
A hand holding a looking glass by a lake
Crowdsource Innovation
Get involved with our crowdsourced digital platform to deliver impact at scale
Stay up to date:

Future of Global Health and Healthcare

A novel combination therapy cures an emerging infectious disease, babesiosis, which is transmitted by the same ticks that transmit the agents of Lyme disease, said Yale researchers. This “radical” therapy not only clears the infection but also prevents the recurrence that often occurs with existing treatments.

The study was published online June 6 in The Journal of Experimental Medicine.

Babesiosis (bab-e-see-oh-sis) is caused by the B. microti parasite, which is most often transmitted through tick bites. It is more common in the Northeast and northern Midwestern states, and likely is on the rise as infected ticks expand geographically. Infected individuals can be asymptomatic, or develop symptoms that range from mild and flu-like to severe and life threatening. The parasite can develop resistance to existing therapies, leading to relapses after treatment.

For their study, the Yale-led team first tested in mice with diminished immune systems four drugs that are currently used in the form of two combinations to treat human babesiosis. Only one of those drugs, atovaquone, was effective in attacking a target enzyme that, when mutated, allows the parasite to develop resistance. Using the mouse model, the team observed efficacy with a fifth drug (ELQ) that involves a similar mechanism of action as atovaquone but at a different enzyme target site. They decided to test the two drugs in combination.

The researchers found that the combination of atovaquone and ELQ-334, at low doses, cleared the infection and prevented recurrence up to 122 days after treatment.

“This is the first radical cure against this parasite,” said Choukri Ben Mamoun, associate professor of infectious diseases. “The novelty of the study was identifying a combination therapy that will both kill the parasite and also paralyze the target enzyme, making it nearly impossible for the parasite to develop resistance.”

The finding is significant since babesiosis is increasing and up to 19% of the ticks and up to 42% of the mammalian hosts (mice and other rodents) that carry the bacteria that cause Lyme disease is co-infected with B. microti.

With this finding, Ben Mamoun and his co-authors can take the next step and pursue studies of the combination therapy in people. “We are developing a better analog for ELQ that will be used in clinical trials. That’s what our future studies will focus on — identifying a better ELQ that could be added to atovaquone. We could test the safety of the compound in humans,” he said.

Other study authors include Lauren A. Lawres, Aprajita Garg, Vidya Kumar, Igor Bruzual, Isaac P. Forquer, Isaline Renard, Azan Z. Virji, Pierre Boulard, Eduardo X. Rodriguez, Alexander J. Allen, Sovitj Pou, Keith W. Wegmann, Rolf W. Winter, Aaron Nilsen, Jialing Mao, Douglas A. Preston, Alexia A. Belperron, Linda K. Bockenstedt, David J. Hinrichs, Michael K. Riscoe, and J. Stone Doggett.

The research was supported by the National Institutes of Health and the U.S. Department of Veterans Affairs Biomedical Laboratory Research and Development.

Don't miss any update on this topic

Create a free account and access your personalized content collection with our latest publications and analyses.

Sign up for free

License and Republishing

World Economic Forum articles may be republished in accordance with the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License, and in accordance with our Terms of Use.

The views expressed in this article are those of the author alone and not the World Economic Forum.

Share:
World Economic Forum logo
Global Agenda

The Agenda Weekly

A weekly update of the most important issues driving the global agenda

Subscribe today

You can unsubscribe at any time using the link in our emails. For more details, review our privacy policy.

Why AI is the new frontier global trade must learn to cross

Patrick McMaster

October 9, 2024

About us

Engage with us

  • Sign in
  • Partner with us
  • Become a member
  • Sign up for our press releases
  • Subscribe to our newsletters
  • Contact us

Quick links

Language editions

Privacy Policy & Terms of Service

Sitemap

© 2024 World Economic Forum