• A new study has shown that physically intense work in hot temperatures could potentially increase US kidney disease rates.
  • However, a significant number of people in America are already at higher risk of obesity, hypertension, and diabetes, which can also contribute to kidney disease.
  • While heat stress could still be a catalyst for kidney disease, more research needs to be carried out to fill the knowledge gap in this area.

Physically demanding work in hot temperatures could increase rates of kidney disease in the United States, a new study shows.

The historic heat wave that hit the Pacific Northwest last month was not just uncomfortable and oppressive—it was deadly.

In Oregon, the triple-digit temperatures that scorched the region were responsible for 116 deaths, according to the Oregon Medical Examiner’s Office, and prompted Governor Kate Brown to order Oregon Occupational Safety and Health to enact emergency rules to protect workers from extreme heat. Climate change trends suggest such heat waves are becoming more common.

Researchers have followed an epidemic of heat-related kidney disease in Central America among workers who toil in the heat, as well as potentially related epidemics in Sri Lanka and India. They say there is growing concern that workers in the United States also are suffering from chronic kidney disease of nontraditional origin.

“With climate change and higher temperatures, we expect this is something the US will be dealing with in the near future,” says Chris Chapman, a postdoctoral researcher who works in the Bowerman Sports Science Center, part of the human physiology department at the University of Oregon.

The problem in the United States could be exacerbated because workers here tend to have higher rates of risk factors that contribute to kidney disease such as obesity, hypertension, and diabetes.

“These other co-morbidities lead us to think this is something the US should be paying attention to,” Chapman says.

It’s possible heat-related kidney disease is less of an issue in the United States because of worker-protection regulations, or it could just be underreported, Chapman says.

For the study, published in the journal Regulatory, Integrative and Comparative Physiology, researchers reviewed the available literature for environmental conditions and physiological strain, such as how much core body temperature increased during a work shift, among occupations that typically experience heat exposure, including farming, wildland firefighting, landscaping, and utility work.

They found “surprisingly limited available evidence” that characterized those exposures among those workers in the United States, supporting the need for further investigation to understand their risk of heat-related kidney disease.

The limited evidence they did find indicated that some workers in the United States may experience conditions that are similar to those in countries with workers that have high rates of chronic kidney disease of nontraditional origin.

“We don’t know the prevalence, and we don’t know the mechanisms that cause it to occur, so we can’t come up with preventative guidelines,” Chapman says.

Chronic kidney disease of nontraditional origin is as high as 42% among sugar cane workers in Nicaragua and also affects nonagricultural sectors in Central America, including construction, brick-making, mining, and fishing, the study finds. No consensus exists about whether these hot spots of kidney disease are caused primarily by occupational heat stress, but it is plausible that heat stress is a catalyst, Chapman says.

Health and healthcare

How is the World Economic Forum bringing data-driven healthcare to life?

The application of “precision medicine” to save and improve lives relies on good-quality, easily-accessible data on everything from our DNA to lifestyle and environmental factors. The opposite to a one-size-fits-all healthcare system, it has vast, untapped potential to transform the treatment and prediction of rare diseases—and disease in general.

But there is no global governance framework for such data and no common data portal. This is a problem that contributes to the premature deaths of hundreds of millions of rare-disease patients worldwide.

The World Economic Forum’s Breaking Barriers to Health Data Governance initiative is focused on creating, testing and growing a framework to support effective and responsible access – across borders – to sensitive health data for the treatment and diagnosis of rare diseases.

The data will be shared via a “federated data system”: a decentralized approach that allows different institutions to access each other’s data without that data ever leaving the organization it originated from. This is done via an application programming interface and strikes a balance between simply pooling data (posing security concerns) and limiting access completely.

The project is a collaboration between entities in the UK (Genomics England), Australia (Australian Genomics Health Alliance), Canada (Genomics4RD), and the US (Intermountain Healthcare).

For example, frequent increases in core temperatures while performing physically demanding work can accelerate existing underlying illness, or it can increase the susceptibility of kidneys to damage during exposure to environmental or chemical toxins.

No study has investigated whether occupational heat exposure increases the risk of kidney disease among US workers, representing “a significant gap in the literature,” the study says.