• US researchers have modelled future scenarios for the future of the COVID-19 pandemic.
  • They project a decline in cases, as a result of a number of factors.
  • The possibility of a new variant emerging could change the trajectory of the pandemic once again.
A nurse prepares a syringe with the COVID-19 Moderna vaccine for a worker of the New York City Fire Department Bureau of Emergency Medical Services (FDNY EMS), amid the coronavirus disease (COVID-19) pandemic. REUTERS/Carlo Allegri
This image shows a nurse preparing a syringe containing a COVID-19 vaccine, which could mark to the end of the pandemic.
Image: REUTERS/Carlo Allegri

The worst of the pandemic may finally be over, according to new modeling results from a consortium of researchers advising the US Centers for Disease Control and Prevention.

The team’s COVID-19 Scenario Modeling Hub, which is co-coordinated by researchers at Penn State, projects that COVID-19 cases will decrease across the United States, barring the emergence of any new variants or major changes in behavior.

“This projected decline in cases could be due to a number of factors, including the availability of vaccines to children ages 5 to 11, which may be available in the next few weeks, and the increasing number of people that are now immune due to either vaccination or natural exposure to the virus,” says Katriona Shea, professor of biology and alumni professor in the biological sciences at Penn State.

The researchers combined nine different mathematical models from different research groups to project the trajectory of the pandemic over the next six months.

“Synergizing results from multiple models has been shown to give much more reliable projections than any one model alone,” says Shea, who published a paper early in the pandemic demonstrating a technique for minimizing uncertainty by combining multiple models together to make projections.

The team specifically examined four potential scenarios, including whether childhood vaccine uptake will be high and whether a more infectious new variant will emerge.

“The most likely scenario is that children age 5 to 11 will be approved for vaccination and that no new superspreading variant will emerge,” says Shea. “In this case, by March 2022, COVID-19 infections across the United States could slowly and steadily drop from about 140,000 per day today to about 9,000 per day, and deaths could decline from about 1,500 per day today to fewer than 100 per day.”

These numbers are similar to those that characterized the US in March 2020 when the virus was just starting to spread throughout the country, adds Shea. They are also lower than the numbers seen in the US earlier this summer, after the vaccines had been available for several months and before the Delta variant had begun to gain the upper hand.

“Importantly,” she says, “the most likely scenario does not project a winter surge.”

Shea notes that, at the state level, however, the team’s results suggest significant variation in projected cases.

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“States, like Florida and Georgia, that have seen high caseloads over the past few months are projected to experience rapid decreases in cases due to high levels of immunity,” she says. “In contrast, states, like Pennsylvania, where the caseloads haven’t been as high in recent weeks may not see the same decline in cases since a greater proportion of people remain vulnerable to infection.”

Vaccine availability to children ages 5 to 11 is also expected to contribute to a drop in COVID-19 cases, with several thousand fewer deaths and tens of thousands of fewer cases across the US. And if a new, more transmissible variant appears, the drop could comprise hundreds of thousands of fewer cases and a similar relative decrease in hospitalizations.

“It’s important to remember that these are not forecasts,” says Shea. “We are thinking about what-ifs, not what is most likely. So, we look at multiple possible scenarios based on different sets of assumptions about possible future conditions. There’s a lot that could change. If we see a new variant or any other unexpected things happen, these long-term trends may not hold. The virus has surprised us again and again.”

Shea notes that by getting vaccinated everyone can play a part in ending the pandemic.

“At the individual level,” she says, “the risk for you and your child decreases significantly if you are all vaccinated.”