International trade and investment drive economic and corporate growth. Shifting geopolitics, business models and societal expectations are tipping global trade and investment into a new phase. Transformations are occurring in global value chains, investment, competition policy, regulatory coherence, digital and services trade, innovation frameworks, sustainable resource management and facilitation, as well as implementation capacity. The time is ripe to set new priorities for trade and investment and secure reform that benefits all stakeholders. However, this requires understanding of the new dynamics of commerce, inspiring narratives, operational and strategic integration, reallocation of resources and results-oriented leadership.