Global Health

TB is a global health problem we can't ignore, but first we need to break the stigma

Clinical lead Doctor Al Story points to an x-ray showing a pair of lungs infected with TB (tuberculosis) during an interview with Reuters  on board the mobile X-ray unit screening for TB in Ladbroke Grove in London January 27, 2014. The only mobile unit testing for TB in the country works with the most vulnerable to the disease including the homeless, drug and alcohol dependent.  REUTERS/Luke MacGregor  (BRITAIN - Tags: HEALTH SOCIETY) - RTX17X9Q

South Africa, as well as having the world’s highest rates of TB, also has the highest rate of HIV associated TB. Image: REUTERS/Luke MacGregor

Paul Mason
Lecturer, Monash University
Anna Coussens
Senior Lecturer, University of Cape Town
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Nearly 70 years ago, a range of antibiotics that could treat tuberculosis were first identified. But today almost two million people still die every year from one of the deadliest infectious diseases. That’s about 5000 people every day. In the face of this tragedy, the ever increasing rise in drug resistant tuberculosis adds to the concern of clinicians and scientists at the front line of TB care and prevention worldwide.

South Africa, as well as having the world’s highest rates of TB, also has the highest rate of HIV associated TB, and one of the largest outbreaks of extremely drug resistant (XDR)-TB. The most likely explanation for the emergence of these bacteria is inadequate or incomplete treatment.

Blame has been pointed at patient (mis)behaviour, funding shortfalls, and technological shortcomings. But it’s time to challenge this dogma. We have ignored that the patient is a victim of poor community prevention programmes that wrongly stigmatise those suffering from the disease. Patients are now more likely to catch drug resistant TB than they are likely to develop resistance by not taking their drugs.

TB patients in low-income settings overcome incredible obstacles in completing their full treatment course. They need to be treated as the true champions in our fight against TB, rather than victims of stigmatisation.

New initiatives to reach out to people whose lives have been affected by TB are needed to reduce the stigmatisation. And communities need to be empowered to recognise and actively challenge their circumstance. The World Health Organisation has recognised this which is why it launched the ZERO Stigma campaign on World TB day this year.

20 000 pills and 200 injections

Clinicians are increasingly finding cases of drug resistant TB and have even been forced to diagnose cases of “totally drug resistant TB” when patients living with TB have become unresponsive to all known antimicrobials.

Standard therapy for TB requires a specially devised combination of antimicrobials. The courses are lengthy. Strains of tuberculosis that are not effectively killed by a standard drug regimen are said to be drug resistant.

People with drug resistant TB bacteria are placed on treatment for at least two years, over which time they receive more than 20,000 pills and 200 injections.

They have a high likelihood of going deaf as a side effect of the drugs and ultimately only have a 30% chance of survival.

Drug resistant TB is increasingly becoming transmitted, rather than acquired. This means that the problem of drug resistance is not merely clinical, but dramatically epidemiological.

In other words, it’s a public health problem. More than that, living in a globalised world where infectious diseases easily cross borders means that TB is a global health problem that none of us should ignore.

For example, a project which tracked 400 XDR-TB patients living in South Africa’s KwaZulu-Natal Province found that between 60% and 80% of these patients had not developed the disease because they were not diligently observing their daily treatment routine of injections and pills.

They caught the bacteria from someone else coughing in their vicinity. This means there aren’t sufficient safety measures to prevent others from also getting infected.

A timeline of the short-lived efficacy of TB antimicrobials from drug discovery to drug resistance. Image: The Conversation
Mobilising Communities to #UnMaskStigma

More outreach campaigns are needed. Public engagement in TB control is limited which is why it outranks infectious diseases such as HIV/AIDS where a cure is unavailable but community support has been strong.

An educational children’s book about tuberculosis has been translated into thirty different languages and has gone into free distribution in The Philippines, Vietnam and the Marshall islands.

If we don’t adequately support the patients to complete appropriate treatment to stop the transmission of TB, then diagnostic shortfalls, treatment shortcomings, and resistance to future drugs will continue to occur.

Laboratory experimentation and clinical research needs to be matched with qualitative studies into the social, economic and political dimensions of TB, with a voice given to people living with this disease.

The current drug resistance problem is caused by diagnostic services, prescribed therapies and public health systems failing the patient, not the patient who fails therapy.

TB drug resistance will not be defeated with novel antibiotic discoveries and new diagnostic technologies alone.

Social and cultural measures have to be considered in the equation too.

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Related topics:
Global HealthBehavioural Sciences
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