Health and Healthcare Systems

Your body clock is so important it just won a Nobel Prize

Circadian rhythms keep living creatures in tune with the rotation of the Earth

Alice Hazelton
Programme Lead, Science and Society, World Economic Forum Geneva
Share:
Our Impact
What's the World Economic Forum doing to accelerate action on Health and Healthcare Systems?
The Big Picture
Explore and monitor how Health and Healthcare is affecting economies, industries and global issues
A hand holding a looking glass by a lake
Crowdsource Innovation
Get involved with our crowdsourced digital platform to deliver impact at scale
Stay up to date:

Health and Healthcare

The most hyped – yet arguably most controversial – week of the science calendar week is here again. The first of this week’s Nobel Prizes to be awarded today is for Physiology or Medicine.

Jeffrey C. Hall, Michael Rosbash and Michael W. Young took 2017’s award “for their discoveries of molecular mechanisms controlling the circadian rhythm”, the internal body clock that dictates when we feel the need to eat and sleep.

Loading...

The three Americans shared the prize of 9 million Swedish kronor (roughly $940,000) equally. Michael Young of Rockefeller University gained recognition for his research on fruit flies, where he isolated the gene that disrupted the circadian clock. Jeffrey Hall and Michael Rosbash, both of Brandeis University, later furthered the work by discovering the fluctuating levels of protein over a 24-hour cycle that the gene causes. The gene encodes a protein within the cell during the night which then degrades during the day.

Their discoveries explain how multicellular organisms, including plants, animals and humans, adapt their biological rhythm so that it is synchronised with the Earth's revolutions.

Understanding how our bodies keep time has "vast implications" for health, said the Nobel committee, who awarded the prize. When working well, our inner clocks adapt our physiology to the dramatically different phases of the day, regulating critical functions such as behaviour, hormone levels, sleep, body temperature and metabolism.

Have you read?

Yet sometimes there is a mismatch between our internal clocks and external cues such as sunlight and temperature. Most of us are familiar with this sensation when we travel across time zones and experience jetlag. The phenomenon of “social jetlag” is also increasingly worrying as people spend more time in artificially lit environments and use digital devices outside of natural daylight hours. The misalignment between our internal and external clocks continues to be cited as a risk factor for various diseases.

Since the seminal discoveries by the three laureates, circadian biology has developed into a vast and highly dynamic research field, with implications for our health and wellbeing that are still to be revealed.

Loading...
Don't miss any update on this topic

Create a free account and access your personalized content collection with our latest publications and analyses.

Sign up for free

License and Republishing

World Economic Forum articles may be republished in accordance with the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License, and in accordance with our Terms of Use.

The views expressed in this article are those of the author alone and not the World Economic Forum.

Related topics:
Health and Healthcare SystemsWellbeing and Mental HealthFourth Industrial Revolution
Share:
World Economic Forum logo
Global Agenda

The Agenda Weekly

A weekly update of the most important issues driving the global agenda

Subscribe today

You can unsubscribe at any time using the link in our emails. For more details, review our privacy policy.

Funding the future: Sustainable financing models to help the fight against antimicrobial resistance

Shyam Bishen

October 10, 2024

About us

Engage with us

  • Sign in
  • Partner with us
  • Become a member
  • Sign up for our press releases
  • Subscribe to our newsletters
  • Contact us

Quick links

Language editions

Privacy Policy & Terms of Service

Sitemap

© 2024 World Economic Forum