Health and Healthcare Systems

Everything you need to know about the Mu COVID-19 variant

a Palestinian health worker administers a dose of Pfizer coronavirus disease (COVID-19) vaccine to a student as a school year begins, in a school near Hebron in the Israeli-occupied West Bank

It's vital that we vaccinate as many people as possible to prevent further new variants. Image: REUTERS/Mussa Qawasma

Paul Griffin
Associate Professor, Infectious Diseases and Microbiology, The University of Queensland
Share:
Our Impact
What's the World Economic Forum doing to accelerate action on Health and Healthcare Systems?
The Big Picture
Explore and monitor how COVID-19 is affecting economies, industries and global issues
A hand holding a looking glass by a lake
Crowdsource Innovation
Get involved with our crowdsourced digital platform to deliver impact at scale
Stay up to date:

COVID-19

Loading...
  • The WHO has identified a new 'variant of interest' called the Mu variant.
  • First discovered in Colombia in January 2021, the Mu variant has so far been in about 39 countries.
  • While the existing vaccines might not cover all the mutations associated with Mu, this variant does not seem to be overtaking Delta.

The World Health Organization has recently named a new “variant of interest” of the coronavirus, called the Mu variant. It was first found in Colombia in January 2021, and has been found in about 39 countries so far.

Mu has changes, called mutations, which mean it might be able to evade some of the protection we get from COVID vaccines.

But one reassuring element is that, despite being around since January 2021, it doesn’t seem to be outcompeting Delta, the dominant variant across most of the world.

If Mu was truly a really bad variant, we would have expected to have started to see indications of this, and we haven’t yet.

What’s a variant of interest?

An impressive element of our COVID response has been frequent genomic sequencing, which we haven’t done before on this scale. This tracks and maps the evolution of the virus in real time, as it adapts and mutates.

Some mutations will be detrimental to the virus, but some will be beneficial, allowing it to spread better, escape the protection offered by vaccines or even evade COVID tests.

If there are changes to the virus that mean it looks like it has the potential to do more harm, then we might designate it a “variant of interest”.

Mu has mutations that might confer some of these properties, but evidence is still emerging.

The four other variants of interest are Eta, Iota, Kappa and Lambda.

If there’s good evidence Mu is more serious and beginning to overtake other variants such as Delta, it might be upgraded to a “variant of concern”. The four variants of concern are Alpha, Beta, Gamma and Delta.

a chart giving details on the four coivd-19 variants of concern identified by the World Health Organisation, alpha, beta, gamma and delta
There are four current variants of concern identified by the World Health Organisation. Image: WHO
Loading...

Can it escape vaccines?

Most COVID vaccines target the “spike protein” of the virus, which it uses to enter our cells. Our vaccines expose our bodies to a part of the virus, commonly the spike protein, so our immune system can learn to fight the virus off if it encounters it.

If a variant has significant changes in the spike protein, this may decrease the effectiveness of our vaccines.

The WHO said preliminary evidence suggests the Mu variant could partially evade the antibodies we get from vaccination.

Have you read?

But because this data is from lab studies, we can’t be sure how the variant will actually play out in the population.

We need more research to be certain about how it behaves in humans, and work on this is ongoing.

The good news is our vaccines currently protect well against symptomatic infection and severe disease from all variants of the virus so far.

Loading...

Vaccines may not protect forever

There’s a high probability a new variant will arise one day that can significantly escape the protection offered by our vaccines, which are based on the original strain of the virus. We would call this an “escape variant”.

It’s hard to know if and when this would happen, but rampant community transmission of the virus increases the chances of such a variant emerging.

However, the leading COVID vaccine manufacturers are well prepared if this eventuates. Some are already developing vaccines for new variants, such as Delta.

If we did discover an escape variant, some vaccine manufacturers could alter their existing vaccines to match the new variant, possibly within 6-8 weeks. Medical regulators around the world would likely accelerate the approval process to make this possible. Certain studies would be required but these could be done quickly, so long as the new vaccine had basically the same properties as the existing vaccine.

Discover

What is the World Economic Forum doing about access to vaccines?

It’s possible we could see a variant overtake Delta in terms of infectiousness eventually. Scientists think it’s at least 50% more infectious than the Alpha variant, which was about 50% more infectious than the original strain.

Evolutionary theory predicts the virus may become more transmissible over time, but less severe, as a virus wants to spread as much as possible and doesn’t want to kill its host before it can do so. But this may not necessarily be how SARS-CoV-2 plays out, and realistically we’re still in the early days of this virus.

The best way of combating variants is to get as many people vaccinated as possible, so there are fewer susceptible hosts for the virus to reproduce and mutate.

Loading...
Don't miss any update on this topic

Create a free account and access your personalized content collection with our latest publications and analyses.

Sign up for free

License and Republishing

World Economic Forum articles may be republished in accordance with the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License, and in accordance with our Terms of Use.

The views expressed in this article are those of the author alone and not the World Economic Forum.

Share:
World Economic Forum logo
Global Agenda

The Agenda Weekly

A weekly update of the most important issues driving the global agenda

Subscribe today

You can unsubscribe at any time using the link in our emails. For more details, review our privacy policy.

3 smart and green innovations making China's healthcare system more sustainable

Ling Liu

June 25, 2024

About Us

Events

Media

Partners & Members

  • Join Us

Language Editions

Privacy Policy & Terms of Service

© 2024 World Economic Forum