• BioNTech is planning to start clinical testing by the end of 2022 for a new malaria vaccine.
  • Malaria kills over 400,000 people each year.
  • The goal of the vaccine is to make the parasite visible and attackable as soon as it enters the body.
  • BioNTech also wants to start creating vaccines for other diseases in 2022, such as tuberculosis and cancer.

BioNTech (22UAy.DE) wants to build on its success in COVID-19 by developing the first vaccine for malaria based on mRNA technology and aims to start clinical testing by the end on 2022, in an attempt to eradicate the mosquito-borne illness.

The Mainz, Germany-based company, which developed a COVID-19 vaccine with its partner Pfizer (PFE.N) in ten months, said on Monday it is also exploring vaccine production in Africa as part of efforts to build up manufacturing capacity on the continent.

"The response to the pandemic has shown that science and innovation can transform people's lives when all key stakeholders work together towards a common goal," said BioNTech Chief Executive and co-founder Ugur Sahin.

Scientists around the world have been working for decades to develop a vaccine to prevent malaria that infects millions of people every year and kills more than 400,000 - most of them babies and young children in the poorest parts of Africa.

Malaria is a complex infection caused by a parasite that evades recognition by the immune system, said Sahin, adding the goal is to develop a vaccine that makes the parasite visible and attackable from the very beginning.

Messenger RNA vaccines prompt the human body to make a protein that is part of the pathogen, triggering an immune response. They are also quicker to develop than traditional vaccines and can be adapted relatively easily.

"The very high efficacy of two mRNA vaccines for COVID-19 have shown the world just how powerful this technology could be against many diseases, including malaria," said World Health Organisation (WHO) head Tedros Adhanom Ghebreyesus, who started his career as a malaria researcher.

The world's first and only licensed malaria vaccine, Mosquirix, was developed by GlaxoSmithKline (GSK.L) over many years of clinical trial across several African countries, but is only around 30% effective.

Researchers at Oxford's Jenner Institute led by Adrian Hill, one of the lead scientists behind the Oxford-AstraZeneca COVID-19 vaccine, are also developing a potential new malaria vaccine that has shown promise in a year-long trial. read more

BioNTech said it will assess multiple vaccine candidates that target the circumsporozoite protein (CSP), as well as new antigens discovered in pre-clinical research and select the most promising for a clinical trial due to start by the end of 2022.

The company is also scouting for suitable mRNA vaccine production sites in Africa, either with partners or on its own, and will receive support from the European Commission, the Bill and Melinda Gates Foundation and other organisations.

BioNTech Chief Operating Officer Sierk Poetting said the company would fund the research and initial production of the vaccine itself and turn to its partners for support with large-scale trials, as well as setting up infrastructure, such as fill and finish sites and providing local training.

Health and healthcare

How is the World Economic Forum bringing data-driven healthcare to life?

The application of “precision medicine” to save and improve lives relies on good-quality, easily-accessible data on everything from our DNA to lifestyle and environmental factors. The opposite to a one-size-fits-all healthcare system, it has vast, untapped potential to transform the treatment and prediction of rare diseases—and disease in general.

But there is no global governance framework for such data and no common data portal. This is a problem that contributes to the premature deaths of hundreds of millions of rare-disease patients worldwide.

The World Economic Forum’s Breaking Barriers to Health Data Governance initiative is focused on creating, testing and growing a framework to support effective and responsible access – across borders – to sensitive health data for the treatment and diagnosis of rare diseases.

The data will be shared via a “federated data system”: a decentralized approach that allows different institutions to access each other’s data without that data ever leaving the organization it originated from. This is done via an application programming interface and strikes a balance between simply pooling data (posing security concerns) and limiting access completely.

The project is a collaboration between entities in the UK (Genomics England), Australia (Australian Genomics Health Alliance), Canada (Genomics4RD), and the US (Intermountain Healthcare).

BioNTech also plans to start a clinical trial to test a vaccine candidate for tuberculosis in 2022 and is working with partners to develop vaccines against nine different infectious diseases as well as for cancer.

(This story corrects mRNA description in paragraph 6 to pathogen from virus)