Agriculture, Food and Beverage

Here’s why cloning could be the future of agriculture

A farmer uses a harvesting machine at a rice field in Ambala in the northern state of Punjab, India, October 10, 2018.  Picture taken October 10, 2018. REUTERS/Adnan Abidi - RC18A21CB450

Farmers use a harvesting machine in a rice field in India Image: REUTERS/Adnan Abidi

Andy Fell
Associate director of News and Media Relations, UC Davis
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Agriculture, Food and Beverage

Plant biologists have discovered a way to make crop plants replicate through seeds as clones.


The discovery, which plant breeders and geneticists have long sought, could make it easier to propagate high-yielding, disease-resistant, or climate-tolerant crops and make them available to the world’s farmers.

Since the 1920s, many crops have been grown from hybrid seeds created by crossing two varieties. These hybrids can have superior qualities in areas such as yield or pest resistance. But the seeds of hybrid crops don’t produce plants with the same qualities.

The ability to produce a clone, an exact replica, of a plant from its seeds would be a major breakthrough for world agriculture. Instead of purchasing expensive hybrid seeds each year, which is often beyond the means of farmers in developing countries, farmers could replant seeds from their own hybrid plants and derive the benefits of high yields year after year.

 Imtiyaz Khanday and Venkatesan Sundaresan stand with the cloned rice plants in a greenhouse in December 2018.
Imtiyaz Khanday and Venkatesan Sundaresan stand with the cloned rice plants in a greenhouse in December 2018. Image: Karin Higgins/UC Davis

About 400 species of wild plants can produce viable seeds without fertilization. Called apomixis, this process seems to have evolved many times in plants—but not in commercial crop species.

“It’s a very desirable goal that could change agriculture,” says Venkatesan Sundaresan, professor of plant biology and plant sciences at the University of California, Davis.

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'Baby Boom' gene

The researchers discovered that the rice gene BBM1, belonging to a family of plant genes called “Baby Boom” or BBM, is expressed in sperm cells but not in eggs. After fertilization, BBM1 is expressed in the fertilized cell but—at least initially—this expression comes from the male contribution to the genome.

BBM1, they reasoned, switches on the ability of a fertilized egg to form an embryo.

The researchers first used gene editing to prevent the plants from going through meiosis, a type of cell division that results in four daughter cells each with half the number of chromosomes of the parent cell. Instead, the egg cells form by mitosis, inheriting a full set of chromosomes from the mother.

Then they caused these egg cells to express BBM1, which they would not normally do without fertilization.

“So we have a diploid egg cell with the ability to make an embryo, and that grows into a clonal seed,” Sundaresan says.

So far, the process has an efficiency of about 30 percent, but the researchers hope they can increase efficiency with more research. The approach should work in other cereal crops, which have equivalent BBM1 genes, and in other crop plants as well, Sundaresan says.

Basic biology, major results

“The beauty of this work is that it addresses fundamental questions in plant biology about how a fertilized egg begins to develop into a new plant,” says Anne Sylvester, a program director at the National Science Foundation, which supported the research.

“This basic understanding, combined with new asexual breeding technologies, opens the door for breakthroughs in plant agriculture by avoiding the loss of beneficial traits that can occur through sexual reproduction.”

The research appears in the journal Nature.

Additional authors of the paper are from UC Davis; Iowa State University; and INRA in Versailles, France. The Innovative Genome Institute, a joint venture between UC Berkeley and UC San Francisco that focuses on applying genome editing to solve global problems, and the National Science Foundation funded the research.

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